The follicle is the basic functional unit of the thyroid and consists of a single layer of cuboidal (follicular) cells around a store of colloid. The concern arises because of the risk of causing tumour cell dissemination into the peritoneal cavity and chest or abdominal wall during the biopsy procedure itself. Breast reconstruction may be performed either at the time of mastectomy or as a delayed procedure. These are also influenced by other factors, such as the iron and vitamin A status, and the acute phase response. They may present as a result of local symptoms, neurological complications or rising thyroglobulin levels. Maceration of the stomach from significant penetrating or blunt injury may require gastric resection. If the presenting problem is melaena alone and no blood is found in the stomach or duodenum on repeat endoscopy, then attention should turn to the small bowel and the colon, and certainly capsule small bowel endoscopy is indicated as this in now the investigative procedure of choice and has replaced all other tests for the diagnosis of obscure bleeding from the small intestine. The treatment of Wilson disease consists of chelation therapy with penicillamine or tientine together with avoidance of food high in copper content. After portal vein decompression, hypersplenism improves in approximately 50% of patients. The contracting muscle bulk restrained by the overlying fascial sheath directly compresses the deep veins and encourages flow from the superficial to the deep venous systems. In some cases, severe dysentery with frank ulceration and massive haemorrhage occurs and is often fatal. Operative reduction is usually possible, although the viability of the bowel may be compromised after reduction and resection is therefore necessary. The pathological process consists of a monoclonal proliferation of spindle (fibrocyte like) cells that are locally invasive with a tendency to recurrence but very rarely metastasize, although instances of peritoneal dissemination have been reported in patients with mesenteric desmoids. The disease is not associated with hyperacidity and, indeed, hypoacidity is frequently encountered, particularly in patients with atrophic gastritis. In the case of bladder tumours, partial, segmental or even total cystectomy may be necessary, particularly when tumours are suspected to be malignant. The excess fat is predominantly macrovesicular fat and usually seen in a perivenular (zone 3) pattern. In advanced cases, there may be evidence of caval compression with lower limb oedema, varicocele, ascites and dilated abdominal wall veins. The incidence of complication is higher in patients with a history of previous gastric surgery, radiotherapy or advanced atherosclerosis. Although very effective in abolishing the bile vomiting, this procedure may lead to bacterial overgrowth, but this is not usually a major problem. The condition corrects itself spontaneously during the first few months of life, probably by further development of the intra-abdominal oesophagus. Increased vascular resistance is both a mechanical consequence of liver architecture distortion and a dynamic process involving active contraction of myofibroblasts, activated stellate cells and venous smooth muscle cells. Local invasion is both horizontal and vertical and, in neglected tumours, can give rise to widespread destruction of the skin and underlying structures. The risk rises after 4 years of pill usage, particularly in women over 30 years on pills of high oestrogen content. Staff should have competencies in monitoring, interpretation and response to the acute deterioration. However, the postoperative management of epidural catheters can be difficult and should be done by the pain team and/or anaesthetist in charge of the patient. The patient should be in the Trendelenburg or at the least supine position until repair or ligation are complete to increase vascular pressure and reduce the risk of air embolus. However, acute presentation with obstruction, anuria and parastomal ileal conduit fistula are well documented. The patient feels the food sticking and often points to a particular site on the sternum, although this does not correlate well with the exact anatomical location of the obstruction. The authors of this chapter believe that it is important to retrieve the maximum number of lymph nodes from any given specimen. The confirmation of an abscess may be difficult and probably many minor collections ultimately resolve and remain unproven. The importance of identification of the medial umbilical ligament is for the surgeon to avoid extending the dissection medial to it as this may risk injury to the urinary bladder.
Nutrients the nutrients are compounded in a multilayer plastic bag under sterile conditions in the pharmacy. Most surgeons would prefer the posterior short loop to the anterior (longer) gastrojejunostomy although there are no comparative trials. The infectivity of leprosy is a function of the concentration of leprosy bacilli in the body of the patient, and the chances of bacteria emerging and remaining viable and pathogenic to susceptible contacts. In extensive injuries and reconstructions thought should also be given to placement of a distal jejunal feeding tube for early enteral access. In selected patients non-invasive positive-pressure ventilation may be helpful in improving oxygenation, and avoiding intubation in up to 82% of patients; however, any patients who manifest signs of respiratory failure should be intubated immediately. Following bariatric surgery, up to 25% of patients may have urinary oxalate levels sufficient to be associated with subsequent renal impairment. Teenage boys undergoing puberty (pubertal gynaecomastia) and elderly men (senescent gynaecomastia) are most commonly affected and between them account for half of the patients with gynaecomastia. Loss of mitochondrial function is associated with electron microscopic structural changes such as membrane thickening, swelling and vacuolization of mitochondria and finally loss of mitochondrial integrity and death. Decisions relating to whether or not high-dependency or intensive care placement is indicated, use of antibiotics and whether early endoscopic retrograde cholangiopancreatography in patients with gallstone disease is indicated can be made upon the basis of whether patients are predicted to be at substantial risk of mortality or septic complications. After initial promising results, other authors were not able to confirm this hypothesis and the concept has been abandoned these days. The injury is probably produced by sudden increases in the intraoesophageal pressure owing to blunt upper abdominal trauma in the presence of a full stomach. Complications Recurrent bacteraemia is the most common complication of pyogenic abscesses. The ultrasound may be falsely reassuring, however, and show non-dilated pelvicalyceal systems and ureters in spite of obstruction in certain conditions, i. A zone of junctional epithelium is interposed between the squamous lining of the oesophagus and the gastric mucosa. Additionally, large tumours are more easily enucleated through the open approach and where necessary, in rare instances, oesophagectomy can also be performed. These patients progress more rapidly to develop cirrhosis and may develop hepatocellular carcinoma. Malignant and premalignant conditions of the skin Cancer of the skin as an overall entity is by far the commonest tumour to affect humans. If there are no obvious bleeding points but generalized ooze, argon beam spray coagulation is the best option. Often difficult to interpret presently not in itself an indication for revascularization. Clinical indications of tamponade include restlessness, inability to lie supine, distended neck veins, muffled heart sounds and pulsus paradoxicus. Generally, asymptomatic or minimally symptomatic individuals are managed conservatively and may be imaged infrequently to ensure that the diverticulum is not growing to a disproportionate size or beginning to cause symptoms. Respiratory disease and smoking the incidence of respiratory disease in surgical patients varies with the population and in Western countries this ranges from 25% to 50%. If this is the case the goals of surgery at the time of the initial procedure should be to control blood loss and contamination; reconstruction should be delayed until restoration of circulating blood volume and normal physiology. Eating pattern There is a decreased risk of oesophageal squamous cell carcinoma but not oesophageal adenocarcinoma with higher intake of both fruit and vegetables. It is further assumed that there is more than one agent and the illness is termed seronegative hepatitis. Missing data Difficulties with obtaining good questionnaire compliance are commonplace in many studies and this can invalidate the results. The trauma surgeon should be aware of what other treatment teams are doing and participate in the decision to alter goals of care from definitive care to damage control for general, neurosurgical and orthopaedic interventions.
These extravasated complexes may contribute to the increased lung water, which may retard the return of pulmonary gas exchange to normal. Distal gastrectomy is selected when a satisfactory proximal margin can be obtained. It is of special importance not to pass the threshold of tolerance of the cardiovascular system and induce congestion. Poor understanding of intrahepatic anatomy in the Western world has also been a contributing factor. In all cases, but particularly with penetrating mechanisms, care should be taken to inspect the groins, axillae and back to ensure no additional injuries are missed. The fat of this layer tends to become more abundant and the connection between the peritoneal membrane and the abdominal wall looser in the lower abdomen and pelvis. Although often associated with rapid gastric emptying, the exact mechanism is unknown. Any penetrating wound in the left thoracoabdominal area should be suspected of causing injury to the stomach and requires investigation of the anterior and posterior surface at the time of laparotomy. Excised specimens should be marked for orientation so that the pathologist can indicate whether any margins of excision are inadequate. Occasionally in elderly or seriously ill people (usually in intensive care), the Tests for Helicobacter pylori infection the most commonly performed are the rapid urease tests. The caudal section of the hepatic anlage ultimately forms the biliary tract and gallbladder while the cephalic section forms the hepatic parenchyma. Remedial surgery should be directed to amelioration of this dominant symptom with the proviso, which must be conveyed to the patient, that while the intended surgery may impart considerable benefit, a totally symptomfree outcome is rarely, if ever, obtained. Skeletal muscle serves as the primary reserve pool of amino acids Metabolic response to trauma Metabolism is the complex system of interrelated biochemical reactions and physiological responses required to maintain life. The genetic information encoding the -lactamase can be transferred between many Gram-negative and Gram-positive bacteria. This hernia can be associated with cardiac anomalies as in the pentalogy of Cantrell. It typically runs over the inferior constrictor muscle to reach and supply the cricothyroid (in some cases, the nerve passes deep to inferior constrictor muscle and is therefore not routinely seen at operation). Roux-en-Y jejunal reconstructions are used when stomach or colon is unavailable and are limited with extent to proximal extension, although optimum mobilization can allow anastomosis above the inferior pulmonary vein. The disease is spread by cyst passers, who fall into two groups: (1) convalescents who have recovered from an acute attack and (2) individuals who can recall no clinical symptoms or signs of infection. Any other symptomatic regions should be examined as required for signs (in a patient with breast cancer) of metastatic disease. It is therefore vital that in the perioperative period insulin administration is not stopped for any significant length of time. Some forms of hepatobiliary disease occur more commonly in patients with inflammatory bowel disease; the lack of oral nutrition leads to biliary sludge and possible changes in intestinal permeability with toxin absorption. Renal abscesses may rupture into the collecting system or into the perinephric space. The disease spreads mainly by direct contact, with considerable destruction of tissue and multiple sinus formation. Patients with obvious lymph node metastases need a central compartment node dissection and lateral compartment node dissection on the involved side. Palliative surgical procedures may be appropriate if there are orthopaedic/ spinal complications. Gastrojejunocolic fistula is an extremely rare complication of benign ulcer disease nowadays and the vast majority of cases are neoplastic in origin. Women at increased risk of breast cancer It is estimated that some 5% of all cases of breast cancer are attributable to inheritance of a gene conferring a high lifetime risk of breast cancer. This reserve is diminished in the stress state owing to decreased delivery from hypovolaemia, hypoxia and acute blood loss anaemia, and increased consumption from the hypermetabolic state. A high index of suspicion should be maintained in pregnant women who present with unexplained cardiovascular collapse, in those who exhibit severe or labile hypertension in early pregnancy, or in patients who have a positive family history. These are benign but may be difficult to distinguish from liposarcomas on histology.
Diagnosis the key to the diagnosis, suspected from the symptoms and signs, is the plain abdominal or chest radiograph taken in the erect position. The most commonly transmitted viral disease is hepatitis C (<1 per 30 000 components transfused). In large hernias the entire stomach and pylorus may be found within the chest inside a large hernial sac, which may also contain the spleen and hepatic flexure of the colon. This provides good postoperative pain relief for a variety of procedures involving the lower abdomen down to the pubic region. Constitutional symptoms include low-grade fever, sore throat, headaches, joint and muscle pain, generalized lymphadenopathy, iridocyclitis and anaemia. Effects of fibrinolytic inhibitors on mortality from upper gastrointestinal haemorrhage. Subdural haematoma Subdural haematoma is a collection of blood in the subdural space and used to be classified according to the age of the haematoma into acute if discovered within 72 hours; subacute if discovered within 3 days to 3 weeks; and chronic if the haematoma was >3 weeks old. Gastric bezoars may be treated conservatively by cellulase enzymatic digestion (300 mL of 0. Controlled clinical studies comparing gastrojejunostomy vs pyloroplasty have not indicated any obvious superiority between these two forms of drainage, but there are some important practical considerations. Oedematous tissue sustains a marked reduction in its tensile strength and, for this reason, when the edges are approximated by sutures, there is a tendency for the sutures to cut through with breakdown of the wound or dehiscence of the anastomosis. Traditional angiography, including surgeon-performed on-table angiography, is both sensitive and specific with a low complication rate. These types of injuries generally heal very well with relatively few complications. Chancroid (soft chancre) this is caused by Haemophilus ducreyi and is transmitted by sexual contact. It is important for surgeons not to mix the approach with the field of lymphadenectomy. Most instances of congenital shortening of the oesophagus are acquired and result from prolonged pathological reflux with fibrosis, ulceration and stricture formation. A careful and systematic approach to the endosonographic assessment of lymph node metastasis can improve staging accuracy. The complex anatomy of the posterior abdominal wall is of great importance during surgery on retroperitoneal organs and retroperitoneal tumours. Increasing use of damage control surgery/temporary abdominal closure may decrease table 14. This can cause injury when passenger space intrusion impacts the occupant, resulting in rib, pelvic and lower extremity fractures; lung contusions; and solid organ injury. Although malabsorption of vitamin B12 is well documented after partial gastrectomy and gastric bypass surgery for morbid obesity, frank megaloblastic anaemia is rare. The history should be directed at detection of pre-existing conditions or medications that may alter management of life-threatening injuries. The skin incision may be longitudinal Femoral hernias the pathogenesis of femoral hernias is now thought to be related to the mode of insertion of the fibres of the transversus abdominis and its investing sheath into the superior pubic ramus and develops in two stages. Enzymes -Lactam resistance in bacteria is the result of the expression of several classes of -lactamase enzymes. Examples of the role of vitamins and the effects of vitamin deficiencies are summarized in Table 12. The parasite lives in the large intestine, causing ulceration of the mucosa with consequent diarrhoea. It may be single, lobulated or multiple and does not show any changes in size with menstruation. Treatment includes adequate sedation, pain control, pharmacological paralysis, nasogastric decompression, percutaneous catheter decompression and surgical decompression. Clinically it may be associated with any combination of eosinophilia, arthralgia and a maculopapular rash and is treated by removal of the offending drug if it can be reliably identified; steroids are sometimes used. Fasting in the patient who is not metabolically stressed leads to preferential mobilization of fat stores that are measured by skin-fold calipers. Thus, material from intra-abdominal abscesses that often contains anaerobic organisms should be aspirated into a sterile syringe and all the air expelled. Duodenal diverticula are managed conservatively unless complications (bleeding or perforation) arise.
Influence of the extent of lymphadenectomy on survival Several authors in Western centres have reported case series of radical lymphadenectomy with improved long-term survival (Altorki and Skinner; Lerut et al. As the hernia enlarges it exits through the superficial inguinal ring behind or above the spermatic cord. There is no evidence that abdominal wound closure with synthetic monofilament biodegradable sutures carries a higher incidence of incisional hernia than closure with nonabsorbable sutures. They enter the transverse foramen at the level of C6, and superior to this point they are contained within the bony vertebral canal before entering the base of the skull through the foramen magnum. The practice of insertion of a nasogastric tube is popular with surgeons but not gastroenterologists. However, if hyperventilation is maintained for more than a few days, cerebral ischaemia will occur. Some studies show that progestogens such as megestrol acetate and soya protein are useful in alleviating menopausal symptoms. Gastrojejunostomy is a safer option when the ulcer area is the seat of an inflammatory mass or when there is significant fibrous scarring. This may be part of Chagas disease, but often the exact cause of the degeneration is not known. Although malignant change has been reported within leiomyomas, it appears to be a rare complication. Mixed tumours these are also recognized, in which varying proportions of the above tumour types are seen. The residual disadvantages are increased hospital (but not total) costs and the need for general or epidural anaesthesia. First, fewer observations may result in the power of the study to detect an effect being compromised. Rarely, the infection may disseminate to the brain, liver and adrenals, and is then usually fatal. Withdrawal of the causative drug (cimetidine, digoxin, spironolactone, anabolic steroids, oestrogen) should result in symptom resolution. Treatment of lesions caused by human papillomavirus infections Methods commonly used to treat cervical lesions include cryosurgery, electrosurgical excision procedure and conization (removal of cone-shaped areas of tissue containing the dysplastic epithelium from the cervix and cervical canal). Reduced serum concentration may reflect a general decrease in protein synthesis with malnutrition and, unlike the other factors, it is thought not to be influenced by the acute phase response. This box is bordered by the clavicles and costal margins superiorly and inferiorly, and bilaterally at the mid-clavicular line. Many of these patients may be managed with sclerotherapy or banding of the varices. Angiotensin-converting enzyme blockers may increase haemodynamic instability during surgery, and some anaesthetists recommend withholding these on the day of surgery. Abdominal and pelvic injuries 315 the bowel wall and mesentery should both be examined for defects, lacerations or haematomas. The volume of liver can then be calculated based on known separation of image slices combined with planar mapping of cross-sectional areas. However, penetrating mechanisms such as stab wounds and gunshot wounds to the trunk or neck should be considered high-level traumas, as should blunt mechanisms that indicate significant force, such as falls over 4. Placement with the aid of screening is important and the use of ultrasound is helpful in minimizing these risks. Systematic, orderly evaluation of the urinary tract reduces the chance of missed injury and limits the number of unnecessary retroperitoneal explorations. Minimizing haemodynamic instability Kidneys receive around 20% of all cardiac output and they are particularly vulnerable to small reductions in blood flow.
Adrenalectomized patients are dependent on lifelong glucocorticoid and mineralocorticoid replacement therapy. Attempts should be made to identify both the superior and inferior glands during lobectomy, but it may sometimes be appropriate to avoid an extensive dissection simply to identify the parathyroid glands as the dissection increases the risk of devascularizing the glands. A large European study reported that <2% of 4000 neuroblastoma patients were over 18 years old. There are insufficient data to recommend specific guidelines in relation to the dose of urokinase and type of antibiotic. In current practice, transcatheter embolization is accepted as a safe and effective treatment modality. Alcoholic hepatitis is an acute severe condition that develops on the background of chronic alcohol use, either in a liver with normal architecture or more usually cirrhosis. Metabolic bone disease in some patients is attributable to previous malnutrition and exposure to corticosteroid therapy. In chronic mucocutaneous candidosis associated with T-lymphocyte immune defects, treatment with transfer factor gives varying results. A well-designed study should lead to a high-quality report, although even a weakly designed study can be well reported, allowing the reader to judge the validity of the study findings. When hypertension persists this may be due to residual tumour, metastatic disease or chronic renal damage secondary to longstanding severe hypertension. These are usually mild anaphylactoid reactions (1:2000 infusions) but serious reactions can occur, although they are rare (1:6000 infusions). The measurement of height will determine growth velocity in the child, a sensitive marker of nutrition and disease. In practice, significant weight loss is usually encountered in patients who obtain a bad functional result and who experience severe postcibal symptoms such that they are afraid to eat. Care is taken to preserve the neurovascular supply to serratus, latissimus and pectoralis major and cutaneous nerves and not to dissect superior to the axillary vein. There are a variety of imaging findings which may assist the identification and characterization of focal liver lesions, but there are very few such lesions which present an absolutely diagnostic appearance on which a clinician can rely with complete confidence. In this group of patients, oesophageal perforation is usually diagnosed during investigations for sepsis. Both acute and chronic parenchymal liver disease can present with features suggestive of surgical pathology; failure to recognize this can have serious consequences and so these conditions should be considered in any differential diagnosis. Pulmonary parenchymal injuries Pulmonary laceration Simple lacerations of the lung parenchyma are common after penetrating trauma but uncommon after blunt trauma. The direct hernia results from a weakness of the posterior wall of the inguinal canal medial to the internal ring and hence the inferior epigastric vessels; the sac is thus in close proximity to the external ring. Open tension-free mesh repairs can be carried out under local anaesthesia as day cases and this reduces the costs considerably. Determinate lesions that progress to clinical disease may arise out of indeterminate ones or de novo. Adrenocortical carcinomas are aggressive malignancies with a high recurrence rate after surgery and a poor response to radiotherapy. Laparoscopic versus open posterior adrenalectomy: a case control study of 100 patients. Mohs micrographic surgery consists of microscopically controlled precise excision of the tumour in increasingly deeper layers until the microscopy shows no tumour cells. It may occur either spontaneously or following transoesophageal echo and cardiac ablation in patients having anticoagulation therapy. A suspicion of renal injury should exist with any penetrating trauma in the vicinity of the renal tract, and in the absence of suspicion for urethral injury a Foley catheter should be inserted.
Using whole genome scanning techniques, such as comparative genomic hybridization or genetic profiling (with microarray or chip-based technology for gene expression or gene deletion), it is clear that individual cancers vary markedly from each other. Splanchnic arteriolar vasodilatation is secondary to elevated circulating levels of vasodilator substances (including glucagon, nitric oxide) and decreased sensitivity of the splanchnic vasculature to endogenous vasoconstrictors. Injection sclerotherapy is not recommended for gastric variceal bleeding following reports of inadequate haemostasis, embolization of sclerosant and ulcer haemorrhage at the site of the injection. Clinical features the majority of gas gangrene infections are exogenous and result from contamination of large wounds as occurs in agriculture tractor injuries, severe comminuted compound fractures sustained in road traffic accidents and battle casualties. Surgical treatment Surgery has an important role but forms part of multidisciplinary treatment. The bleeding from puncture site(s) following percutaneous interventions may be substantial if a major intrahepatic vessel is damaged. Rarely, the disease may develop in patients with congenital hereditary and non-hereditary lymphoedema. Fibroepithelioma of Pinkus In this variant, strands of basiloid cells extend into the deeper fibrous stroma but there is no palisading. In those cases the majority of patients present with severe sepsis, cerebral abscesses and diminished level of consciousness that requires admission to the intensive care unit. It is usually difficult to recognize and, on many occasions, it can only be diagnosed retrospectively on taking a detailed history or after surgery. Subphrenic extrahepatic abscess the distribution of intra-abdominal abscesses is directly related to the precipitating lesion and to the potential peritoneal spaces. Decreased capillary endothelial integrity in the injured lung makes judicious fluid management in the patient with pulmonary contusion essential. Clinical features Plasmodiumfalciparum this is the only type of malaria that may be directly fatal. Conventional indications for endoscopic resections are (1) differentiated adenocarcinoma confined to mucosa; (2) elevated lesion less than 2 cm; and (3) depressed type without an ulcer in less than 1 cm. Morbidity of therapy Follow-up is also an opportunity to assess the morbidity of treatment, especially locoregional or systemic effects. They may be used for localization of a known or suspected lesion and aid in planning the operative approach. The review included different interventions such as rigid plastic intubation, self-expanding metallic stent insertion, brachytherapy, external beam radiotherapy, chemotherapy, oesophageal bypass surgery, and chemical and thermal ablation therapy. Clinical picture the clinical presentation depends on the cause and onset of perforation, site of perforation and the extent of perforation and subsequently the degree of contamination and its systemic effect. However, fluorinated polyester mesh that can be gel impregnated for antibiotic bonding immediately before use has been shown experimentally to induce minimal adherence to bowel and this material exhibits minimal contraction and hardening with time. Following the exclusion of a phaeochromocytoma, fine needle aspiration cytology can be selectively and carefully employed if a secondary adrenal malignant deposit is suspected. However, if the presentation is late or surgical treatment is delayed beyond 8 hours from the onset of symptoms, or if the patient has chronic respiratory problems, the use of a broad-spectrum antibiotic (usually a secondgeneration cephalosporin) is justified. As well as being a minimally invasive technique, embolization has the advantage of being suitable for surgically unfit patients and repeatable in cases of persistent bleeding. A strong suture is tied around the central axle of the stapler gun before it is closed and fired. Diagnosis can be quite difficult as clinical findings are likely to be non-specific or non-existent. Autoimmune gastritis is a relatively rare disease, most frequently encountered in individuals of northern European descent and blacks. Some have found the procedure beneficial and have extended its use as a prophylactic measure in the treatment of patients with generalized peritonitis and following major abdominal surgical procedures. Sepsis 129 bronchial lavage provides more accurate results in patients with artificial airways. The concentration of gastrin in the plasma can be measured by specific radioimmunoassay.
Ligation of the portal vein may result in splanchnic hypervolaemia, and systemic hypovolaemia causing haemodynamic compromise. Disseminated intravascular coagulation and impaired liver synthesis can occur following liver injury and resection and replacement of coagulation factors and intravascular blood volume are essential during resuscitation. Although most cystic hygromas are multicystic, in 10% of cases they consist of a unilocular cyst. It occurs in association with virilization, acne and amenorrhoea in the young female, virilization in a prepubital female and feminization in the male. A nagging, ill-defined, low back pain is common and there may be evidence of venous obstruction as shown by swelling of the scrotum and legs. Circulating antibodies against mitochondrial constituents (antimitochondrial antibodies) are found in all patients. The rigid cells block the microcirculation to various organs, inducing episodes of pain and infarction (joints, small bones of the hands and feet, spleen, etc. High-dose intravenous human immunoglobulin can produce remissions of varying duration. Occasional involvement of the spleen and kidneys by solitary cysts is well documented. Thus infection in healthcare workers and homosexuals (who have accepted the vaccination programme) has fallen. Reconstruction is associated with better functional outcomes than ligation; therefore, ligation should be reserved for cases of Subclavian vascular injuries Subclavian vessel injuries are primarily due to penetrating mechanisms, but are rare, affecting <3% of all penetrating traumas. If a patient develops a high temperature in the postoperative period, the following are necessary in all patients: physical examination of the lungs, wound, calves and urine. These viral infections cause an initial, often mild and inconsequential, primary infection, following which the virus remains dormant in a non-infectious state (latent) at certain sites. Most subhepatic abscesses may be drained surgically by an anterior approach, as may the right anterior subphrenic collection. However, the previously held view that Hb is nephrotoxic has been shown to be incorrect. Adequate drainage of sepsis needs monitoring of patient condition and imaging the progress of the size of residual collections related to the leak. A pseudoaneurysm may cause symptoms by encroachment on local structures as it expands or it may present acutely with rupture, distal embolization or thrombosis. Thyrotoxicosis is defined as excess levels of circulating thyroid hormones, which includes hyperthyroidism but also other uncommon conditions in which Other causes of primary thyrotoxicosis Plummer disease (described originally in 1913) is the term given to a hyperfunctioning thyroid, which may be either multinodular or a solitary nodule. Abnormalities associated with thoracic aortic injury include widened mediastinum (>8 cm), apical capping, left pleural effusion, loss of the aortopulmonary window, depression of the left mainstem bronchus, deviation of the trachea or nasogastric tube to the right, and widening of the right paratracheal stripe. True congenital shortening of the oesophagus in infancy and childhood is very rare. Oesophageal injuries should be widely explored to ensure the entire mucosal defect is seen. Radiology Barium swallow with fluoroscopy has traditionally been the first-line investigation for suspected achalasia. Acute dilatation of the stomach is well documented in patients (usually young females) suffering from anorexia nervosa or bulimia (compulsive eating followed by self-induced vomiting), and instances of gastric necrosis and rupture of the stomach have been reported in these patients. The umbilical fissure and the falciform ligament are the most conspicuous anatomical landmarks and divide the liver into right and left lobes. Some instances of pyloric stenosis are, however, caused by inflammatory oedema surrounding an active ulcer, and these often resolve with medical conservative treatment. Surprisingly, symptomatic gastric retention is rarely encountered, although postprandial fullness is common and the patient should be advised to avoid heavy bulky meals, lying down after meals and to eat the evening meal at least 3 hours before retiring to bed. Transfusion haemosiderosis Every unit of blood contains 250 mg of iron that is retained by the body.